This technical note supports the development of preparedness and response plans for addressing the impact of the COVID-19 pandemic on girls and women at risk of and affected by female genital mutilation. While the technical note is intended for UNFPA and UNICEF Joint Programme staff and implementing partners, other UN agencies, governments, civil society, and non-governmental organizations (NGOs) may find it beneficial as well. The brief in no way suggests a “one size fits all” approach. Prevention and containment measures (e.g., gathering restrictions and quarantine) are contextual and may shift over time. For this reason, assessing the implications of COVID-19 on current female genital mutilation programmes is critical in understanding how the pandemic increases girls’ and women’s vulnerability and marginalization.